C 5 Recombinant Factor I Modules of C 7 Bind to Complement Components

Domain of C 5 Recombinant Factor I Modules of C 7 Bind to Complement Components C 5 and C 7

Domain of C 5 Recombinant Factor I Modules of C 7 Bind to Complement Components C 5 and C

The C345c Domain of C5 Recombinant Factor I Modules of C7 Bind to Complement Components C5 and C7

A recombinant two-module form of human properdin is an inhibitor of the complement alternative pathway.

Properdin upregulates the alternative complement pathway by binding and stabilising the C3 convertase complex (C3bBb). Properdin is a soluble glycoprotein and its flexible rod-like 53kDa monomers form cyclic polymers (dimers, trimers, tetramers and pentamers). The properdin monomer consists of seven thrombospondin type I repeats (TSR 0-6), which are similar and homologous to domains found in ci...

Identification of the second heparin-binding domain in human complement factor H.

Complement factor H (fH) regulates activation of the alternative pathway of C, reducing the amount of C3b deposited on sialic acid-rich surfaces. Heparin binding has been used as a model for examining the sialic acid-binding characteristics of fH. We have previously shown that of the 20 short consensus repeat (SCR) modules of fH, SCR 7 contains an important heparin binding site, but other SCRs ...